Sgoifo A, Stilli D, Aimi B, Parmigiani S, Manghi M, Musso E
Dipartimento di Biologia e Fisiologia Generali, Università di Parma, Italy.
Physiol Behav. 1994 Feb;55(2):209-16. doi: 10.1016/0031-9384(94)90125-2.
Telemetry ECGs were recorded from Wistar male rats during social stress induced by exposure to aggressive lactating female rats. Behavioral response to maternal attack was evaluated in terms of relative duration of passive submissive (p/s) and active/nonsubmissive (a/ns) patterns. A decrease of R-R interval (R-R) compared to baseline conditions was found, significantly more pronounced than that observed in control animals exposed just to novel environment. R-R variability during social stress was positively correlated with the amount of p/s behavior. R-R fluctuations, episodes of II degree A-V block, and ventricular arrhythmias were also observed. Most R-R fluctuations and II degree A-V blocks were temporally associated with phases of p/s behavior and periods of high R-R variability. Ventricular arrhythmias generally appeared during a/ns behavior and were temporally linked with periods of low R-R variability. Ventricular arrhythmias, low R-R variability, and concomitant a/ns behavior might be related to an increased sympathetic activity. R-R fluctuations and II degree A-V blocks, associated with high R-R variability and p/s behavior, might be related to a predominant inhibitory effect of vagal activation (accentuated antagonism).
在暴露于具有攻击性的哺乳期雌性大鼠所诱发的社会应激期间，对Wistar雄性大鼠进行遥测心电图记录。根据被动顺从（p/s）和主动/不顺从（a/ns）模式的相对持续时间来评估对母鼠攻击的行为反应。发现与基线条件相比，R-R间期（R-R）缩短，且比仅暴露于新环境的对照动物中观察到的更为明显。社会应激期间的R-R变异性与p/s行为的量呈正相关。还观察到R-R波动、二度房室传导阻滞发作和室性心律失常。大多数R-R波动和二度房室传导阻滞在时间上与p/s行为阶段和高R-R变异性时期相关。室性心律失常通常出现在a/ns行为期间，并且在时间上与低R-R变异性时期相关。室性心律失常、低R-R变异性和伴随的a/ns行为可能与交感神经活动增加有关。与高R-R变异性和p/s行为相关的R-R波动和二度房室传导阻滞可能与迷走神经激活的主要抑制作用（增强的拮抗作用）有关。
