利用氟代脱氧葡萄糖正电子发射断层扫描（FDG PET）、计算机断层扫描（CT）及融合图像对纵隔非小细胞肺癌进行分期：初步前瞻性评估
Staging of mediastinal non-small cell lung cancer with FDG PET, CT, and fusion images: preliminary prospective evaluation.
作者信息
Wahl R L, Quint L E, Greenough R L, Meyer C R, White R I, Orringer M B
机构信息
Department of Internal Medicine (Division of Nuclear Medicine), University of Michigan Medical Center, Ann Arbor 48109-0028.
出版信息
Radiology. 1994 May;191(2):371-7. doi: 10.1148/radiology.191.2.8153308.
PURPOSE
To evaluate use of positron emission tomography (PET) with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) in detection of mediastinal lymph node metastases from non-small cell lung cancer.
MATERIALS AND METHODS
A prospective trial to compare FDG PET and computed tomography (CT) of the thorax was performed in 23 patients with newly diagnosed or suspected non-small cell lung cancer. Blinded interpretations of CT alone, PET alone, CT and PET together, and fusion images were performed, and the results were compared with pathologic results.
RESULTS
Nineteen of 23 patients had non-small cell lung cancer. Prevalence of mediastinal involvement was 41%. In staging disease in the mediastinum, CT alone was 64% sensitive, 44% specific, and 52% accurate, whereas PET alone and fusion images were 82% sensitive, 81% specific, and 81% accurate (P < .05).
CONCLUSIONS
FDG PET was more accurate than CT in staging disease in the mediastinum in patients with lung cancer and appears to be the preferred imaging method in this clinical setting.
目的
评估使用2-[氟-18]-氟-2-脱氧-D-葡萄糖（FDG）正电子发射断层扫描（PET）检测非小细胞肺癌纵隔淋巴结转移的情况。
材料与方法
对23例新诊断或疑似非小细胞肺癌患者进行了一项前瞻性试验，比较胸部FDG PET和计算机断层扫描（CT）。对单独的CT、单独的PET、CT和PET联合以及融合图像进行盲法解读，并将结果与病理结果进行比较。
结果
23例患者中有19例患有非小细胞肺癌。纵隔受累的患病率为41%。在纵隔疾病分期中，单独的CT敏感性为64%，特异性为44%，准确性为52%，而单独的PET和融合图像敏感性为82%，特异性为81%，准确性为81%（P <.05）。
结论
在肺癌患者的纵隔疾病分期中，FDG PET比CT更准确，似乎是这种临床情况下的首选成像方法。
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