White P H
Division of Pediatric and Adult Rheumatology, Children's National Medical Center, Washington, DC.
Rheum Dis Clin North Am. 1994 Feb;20(1):119-27.
The clinical manifestations of pediatric systemic lupus erythematosus (SLE) are similar to those seen in adults with SLE with increased frequency of the following features: hepatosplenomegaly, chorea, nephritis, and avascular necrosis. Similarly, pediatric SLE patients are now showing the same improvement in survival as adult SLE patients, and it is no longer felt that the course of childhood-onset SLE is more severe than that seen in adult-onset SLE. Children of mothers with SLE can develop both transient and persistent features of SLE in the neonatal period. Transient features include photosensitive discoid rash, cytopenia, hepatosplenomegaly, myocarditis, and pericarditis; the permanent features include congenital complete heart block, endomyocardial fibroelastosis, and other structural cardiac defects.
儿童系统性红斑狼疮（SLE）的临床表现与成人SLE相似，以下特征出现的频率增加：肝脾肿大、舞蹈病、肾炎和无血管性坏死。同样，儿童SLE患者目前在生存率方面与成人SLE患者有相同的改善，并且不再认为儿童期发病的SLE病程比成人期发病的SLE更严重。患有SLE的母亲的孩子在新生儿期可出现SLE的短暂和持续特征。短暂特征包括光敏性盘状皮疹、血细胞减少、肝脾肿大、心肌炎和心包炎；永久性特征包括先天性完全性心脏传导阻滞、心内膜弹力纤维增生症和其他结构性心脏缺陷。
