Halter F
Abteilung für Gastroenterologie, Inselspital, Bern.
Schweiz Med Wochenschr. 1994 Mar 12;124(10):421-5.
The development of fiberoptic endoscopy, the creation of drugs with well understood mechanisms of action, and the definition of the role of Helicobacter pylori have resulted in a considerably better understanding of ulcer pathogenesis. This has led to rational concepts of ulcer therapy, which are discussed in detail in this review. Moreover, the role of non-steroidal antiinflammatory drugs in peptic ulcer disease, and the use of drugs and endoscopic measures in treatment of ulcer complications, especially g.i. hemorrhage, are discussed in detail. The implications of these advances with regard to the indications for surgical treatment of peptic ulcer disease are outlined.
纤维内镜的发展、作用机制明确的药物的研发以及幽门螺杆菌作用的明确，使人们对溃疡发病机制有了更深入的了解。这催生了合理的溃疡治疗理念，本综述将对此进行详细讨论。此外，还将详细讨论非甾体抗炎药在消化性溃疡疾病中的作用，以及药物和内镜措施在溃疡并发症（尤其是胃肠道出血）治疗中的应用。本文还概述了这些进展对消化性溃疡疾病手术治疗指征的影响。
