Gupta V P, Aggarwal R, Aggarwal S
Department of Ophthalmology, University College of Medical Sciences, Delhi, India.
Acta Ophthalmol (Copenh). 1993 Dec;71(6):839-40. doi: 10.1111/j.1755-3768.1993.tb08611.x.
Due to presence of trachoma in a large percentage of cases of conjunctival amyloidosis, trachoma has been blamed for causing secondary localized amyloidosis. However, there is no study to demonstrate evidence of amyloidosis in tarsoconjunctival specimens of trachomatous lids. 50 eyes of 35 patients having trachomatous eyelids with thickened tarsal plate, trichiasis and entropion had a tarsoconjunctival biopsy (3 mm x 20 mm) from the upper lid. Histopathological examination using Haematoxylin--eosin and congo red stains failed to reveal evidence of amyloid deposition in any of the biopsies. This is the first histopathological study of amyloidosis in trachomatous patients. Our study rules out the long-standing concept of trachoma having causal relationship with conjunctival amyloidosis. It is concluded that conjunctival amyloidosis occurring in trachomatous lids should be considered as primary localized amyloidosis.
由于在很大比例的结膜淀粉样变性病例中存在沙眼，沙眼一直被认为是导致继发性局限性淀粉样变性的原因。然而，尚无研究能证明沙眼性眼睑的睑结膜标本中存在淀粉样变性的证据。对35例患有沙眼性眼睑（睑板增厚、倒睫和睑内翻）的患者的50只眼睛进行了上睑睑结膜活检（3毫米×20毫米）。使用苏木精-伊红和刚果红染色进行组织病理学检查，结果显示在任何活检标本中均未发现淀粉样沉积的证据。这是对沙眼患者淀粉样变性的首次组织病理学研究。我们的研究排除了沙眼与结膜淀粉样变性存在因果关系这一长期以来的观念。得出的结论是，发生在沙眼性眼睑的结膜淀粉样变性应被视为原发性局限性淀粉样变性。
