de M Barros S B, Saliba A M
Toxicology. 1978 Jul;10(3):271-9. doi: 10.1016/0300-483x(78)90077-x.
Three groups, with 10 sixty-day-old male rats each, were given dietary levels of technical hexachlorocyclohexane (HCH) 0, 0.9 and 900 ppm for 90 days. Observations were made on blood glucose, live glycogen and glucose-6-phosphatase (G-6-Pase), organ weights, histology and histochemistry of different tissues. Significant findings included growth retardation at 900 ppm, increased relative liver weight at the same dietary level, reduction of blood glucose levels at 0.9 ppm while liver glycogen and G-6-Pase levels were not affected in any dosage. Histological and histochemical changes were seen only in liver and kidneys, including steatosis and gutular hyaline degeneration in the kidneys of animals receiving dietary levels of technical HCH 900 ppm.
将三组每组10只60日龄雄性大鼠，分别给予0、0.9和900 ppm工业级六氯环己烷（HCH）的饮食水平，持续90天。对血糖、肝糖原和葡萄糖-6-磷酸酶（G-6-Pase）、器官重量、不同组织的组织学和组织化学进行了观察。显著发现包括900 ppm时生长迟缓，相同饮食水平下相对肝脏重量增加，0.9 ppm时血糖水平降低，而肝糖原和G-6-Pase水平在任何剂量下均未受影响。仅在肝脏和肾脏中观察到组织学和组织化学变化，包括接受900 ppm工业级HCH饮食水平的动物肾脏中的脂肪变性和肾小球透明变性。
