Solov'eva N I
Bioorg Khim. 1994 Feb;20(2):143-52.
Metalloproteinases play a key role in the destruction of connective tissue matrix both upon normal physiological processes associated with remodelling of connective tissue and in various pathological situations. Variability of the matrix metalloproteinases, their specificity, structural features, activity regulation in vitro and in vivo, as well as their role in processes of oncogenic transformation are reviewed.
金属蛋白酶在结缔组织重塑相关的正常生理过程以及各种病理情况下，对结缔组织基质的破坏中起关键作用。本文综述了基质金属蛋白酶的变异性、特异性、结构特征、体内外活性调节以及它们在致癌转化过程中的作用。
