Matakas F, Eibs G, Cuypers J
J Neurol Neurosurg Psychiatry. 1975 Dec;38(12):1206-10. doi: 10.1136/jnnp.38.12.1206.
In five baboons and 11 cats cerebral ischaemia was produced either by inflating an epidural balloon and or by ligating major arteries supplying the brain. Fifteen of the animals developed intracranial hypertension after cerebral ischaemia. If ICP were high, but still significantly lower than MABP, elevation of MABP by noradrenaline infusions was accompanied by a proportional increase of ICP. However, the increase of ICP was lower than that of MABP so that CPP was raised. CBF measured by the 133Xenon clearance technique was significantly increased by arterial hypertension in eight cases. The proportional increase of CPP and CBF by elevation of arterial blood pressure was substantially greater, the lower ICP was immediately after ischaemia. There was no effect of MABP in cases in which ICP equalled MABP.
在5只狒狒和11只猫中，通过向硬膜外气囊充气和/或结扎供应大脑的主要动脉来制造脑缺血。15只动物在脑缺血后出现颅内高压。如果颅内压升高，但仍显著低于平均动脉压，通过输注去甲肾上腺素升高平均动脉压会伴随颅内压成比例升高。然而，颅内压的升高低于平均动脉压的升高，因此脑灌注压升高。通过133氙清除技术测量的脑血流量在8例中因动脉高血压而显著增加。缺血后颅内压越低，通过升高动脉血压使脑灌注压和脑血流量成比例增加的幅度就越大。当颅内压等于平均动脉压时，平均动脉压没有影响。
