Andersson G, Andersson L, Larhammar D, Rask L, Sigurdardóttir S
Dept of Cell Research, Uppsala Genetic Center, Swedish University of Agricultural Sciences.
Immunol Today. 1994 Feb;15(2):58-62. doi: 10.1016/0167-5699(94)90134-1.
The DR haplotypes of the human major histocompatibility complex have been arranged in five haplotypic groups based on genomic cloning and sequence analyses. To date, the expressed DRB sequences have been assigned to four different loci: DRB1, 3, 4 and 5. DRB1 alleles are present in all haplotypes, whereas DRB3, 4 and 5 are present only in some haplotypes. Here, Göran Andersson and colleagues suggest that DRB3, 4 and 5 sequences may be treated as a single allelic series. They argue that such a model is appropriate, since DRB3, 4 and 5 sequences are inherited in an allelic fashion, have similar genomic localization, exhibit similar levels of gene expression and are, with a few rare exceptions, not present in the same haplotype.
人类主要组织相容性复合体的DR单倍型已根据基因组克隆和序列分析被排列为五个单倍型组。迄今为止，已表达的DRB序列已被指定到四个不同的基因座：DRB1、3、4和5。DRB1等位基因存在于所有单倍型中，而DRB3、4和5仅存在于某些单倍型中。在此，戈兰·安德森及其同事提出，DRB3、4和5序列可被视为一个单一的等位基因系列。他们认为这样的模型是合适的，因为DRB3、4和5序列以等位基因方式遗传，具有相似的基因组定位，表现出相似的基因表达水平，并且除了少数罕见例外，不存在于同一单倍型中。
