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Study of anticancer drug interaction with DNA by means of particle-induced desorption mass spectrometry: prospydine and deoxyguanosine-5'-monophosphate.

作者信息

Sukhodub L F, Grebenik L I, Chivanov V D

机构信息

Institute of Applied Physics, Academy of Sciences of Ukraine, Sumy.

出版信息

Rapid Commun Mass Spectrom. 1994 Feb;8(2):195-8. doi: 10.1002/rcm.1290080214.

DOI:10.1002/rcm.1290080214
PMID:8155899
Abstract

Using 252CF particle desorption mass spectrometry, the interaction between an antitumour drug prospydine (Pro) and deoxyguanosine-5'-monophosphate (pdG) has been studied. The adduct which corresponds to a peak at m/z 524.5 and which occurs as a result of the particular degradation of Pro during its alkylating of pdG has been found.

摘要

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