Terada N, Konno A, Shirotori K, Fujisawa T, Atsuta J, Ichimi R, Kikuchi Y, Takaki S, Takatsu K, Togawa K
Department of Otorhinolaryngology, Akita University, School of Medicine, Japan.
Int Arch Allergy Immunol. 1994;104 Suppl 1(1):18-20. doi: 10.1159/000236740.
Kimura's disease is a chronic granulomatous disease of unknown etiology. Although eosinophilia is one of the characteristic features in this disease, little is known about the mechanism of eosinophilia. In the present study it was demonstrated that interleukin-5 (IL-5) was produced and released from the site of a granuloma and lymph nodes after stimulation with candida antigen. It was also shown that peripheral blood eosinophils from patients with Kimura's disease contained a large proportion of hypodense eosinophils and that their viability was prolonged. These results strongly suggest that locally produced IL-5 induced by candida antigen contributes to the eosinophilia in this disease.
木村病是一种病因不明的慢性肉芽肿性疾病。尽管嗜酸性粒细胞增多是该疾病的特征之一，但对嗜酸性粒细胞增多的机制知之甚少。在本研究中，已证实白色念珠菌抗原刺激后，肉芽肿和淋巴结部位可产生并释放白细胞介素-5（IL-5）。还发现木村病患者外周血嗜酸性粒细胞中低密度嗜酸性粒细胞比例较高，且其存活期延长。这些结果强烈表明，白色念珠菌抗原诱导局部产生的IL-5促成了该疾病中的嗜酸性粒细胞增多。
