Long survival in patients with acquired immune deficiency syndrome-related primary central nervous system lymphoma.
作者信息
Chamberlain M C
机构信息
University of California, Department of Neurosciences, San Diego 92103.
出版信息
Cancer. 1994 Mar 15;73(6):1728-30. doi: 10.1002/1097-0142(19940315)73:6<1728::aid-cncr2820730629>3.0.co;2-8.
BACKGROUND
Primary central nervous system lymphoma (PCNSL) is the most common brain tumor occurring in patients with acquired immune deficiency syndrome (AIDS). After diagnosis of PCNSL, the median survival time is 2-5 months with treatment with whole brain irradiation (WBI).
METHODS
Four (of approximately 40) patients with AIDS and PCNSL seen by the University of California, San Diego (UCSD) Neuro-Oncology service were treated with multimodal therapy, including WBI with hydroxyurea, followed by 3 cycles of procarbazine/lomustine/vincristine (PCV) chemotherapy.
RESULTS
Survival after tumor diagnosis ranged from 11 to 16 months, with a median of 13.5 months.
CONCLUSION
Selected patients with AIDS and PCNSL may have long survival when treated with multimodal therapy.
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