Wurpel J N, Iyer S N
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St. John's University, Jamaica, New York 11439.
Epilepsia. 1994 Mar-Apr;35(2):443-9. doi: 10.1111/j.1528-1157.1994.tb02458.x.
The calcium channel blockers verapamil (VPM) and nimodipine (NMD) were administered to adult or immature (16-day-old) rats to determine their effects on amygdala-kindled seizures. The afterdischarge threshold (ADT) kindling rate and degree of postictal refractoriness were determined for two doses of VPM (0.5 and 5.0 mg/kg in rat pups and 2 and 10 mg/kg in adult rats) or 30 mg/kg nimodipine (NMD). Neither VPM nor NMD affected the ADT of the amygdala in adult or immature rats. VPM retarded the rate of kindling in both adult and immature rats in a dose-dependent manner; the number of stimulations required to progress through seizure stages were increased. NMD 30 mg/kg reduced the kindling rate and AD duration in both adult and immature rats. Neither drug was able to suppress recurrent seizures elicited by repetitive stimulation. These results suggest that verapamil, and possibly NMD may be of clinical utility in treatment of epilepsy, especially complex partial seizures.
将钙通道阻滞剂维拉帕米（VPM）和尼莫地平（NMD）给予成年或未成熟（16日龄）大鼠，以确定它们对杏仁核点燃性癫痫发作的影响。测定了两种剂量的VPM（幼鼠为0.5和5.0mg/kg，成年大鼠为2和10mg/kg）或30mg/kg尼莫地平（NMD）的放电后阈值（ADT）、点燃率和发作后不应期程度。VPM和NMD均未影响成年或未成熟大鼠杏仁核的ADT。VPM以剂量依赖性方式延缓成年和未成熟大鼠的点燃率；进入癫痫发作阶段所需的刺激次数增加。30mg/kg的NMD降低了成年和未成熟大鼠的点燃率和AD持续时间。两种药物均不能抑制重复刺激引起的复发性癫痫发作。这些结果表明，维拉帕米以及可能的尼莫地平在癫痫治疗中，尤其是复杂部分性癫痫中可能具有临床应用价值。
