Ellis R W, Douglas R G
Int J Technol Assess Health Care. 1994 Winter;10(1):185-92. doi: 10.1017/s0266462300014112.
The availability of new vaccines for pediatric use provides an unprecedented opportunity to prevent serious infectious diseases and their associated morbidity and mortality. However, each new product entails the need for additional injections that could become so numerous as to discourage the administration of new vaccines. This challenge can be overcome by mixing individual vaccines before delivery such that multiple vaccines are administered as single combination vaccines. Technical, clinical, manufacturing, regulatory and marketing issues relative to combination vaccines in general are the major challenges for ongoing and future development.
新型儿科用疫苗的出现为预防严重传染病及其相关的发病率和死亡率提供了前所未有的机会。然而，每种新产品都需要额外注射，注射次数可能会变得过多，从而导致人们不愿接种新疫苗。通过在交付前将单一疫苗混合，使多种疫苗作为单一联合疫苗进行接种，可以克服这一挑战。一般而言，与联合疫苗相关的技术、临床、生产、监管和营销问题是当前及未来发展的主要挑战。
