Bottermann P, Schweigart U, Ermler R
Med Klin. 1976 Feb 13;71(7):275-80.
Intravenous glucose tolerance tests were performed and changes of blood glucose and insulin concentration were measured to examine whether the diabetogenic effect of glucocorticoides can be compensated by biguanides. Seven standard weight volunteers with a healthy metabolism were given prednisolone and buformin as well as a combination of both. In spite of the reactively higher insulin secretion after treatment with prednisolone the glucose tolerance was reduced. In contrast, treatment with biguanide improved the glucose tolerance while decreasing the insulin secretion. It was nearly possible to compensate the negative effect of prednisolone on the carbohydrate metabolism by biguanides. We, therefore, consider a preventive administration of biguanides to be effective in long term or high dosage administration of glucocorticoides.
进行了静脉葡萄糖耐量试验，并测量血糖和胰岛素浓度的变化，以检查双胍类药物是否能够补偿糖皮质激素的致糖尿病作用。对7名代谢健康的标准体重志愿者给予泼尼松龙、二甲双胍以及二者的组合。尽管使用泼尼松龙治疗后胰岛素分泌反应性升高，但葡萄糖耐量仍降低。相比之下，双胍类药物治疗可改善葡萄糖耐量，同时降低胰岛素分泌。双胍类药物几乎可以补偿泼尼松龙对碳水化合物代谢的负面影响。因此，我们认为预防性给予双胍类药物对于长期或高剂量使用糖皮质激素是有效的。
