Massion W, Blümel G, Erhardt W, Krueger P, Petrowicz O, Wendt P, Heinkelmann W
MMW Munch Med Wochenschr. 1976 Feb 13;118(7):197-202.
Our experiments have shown that in cats in the early phase after experimental myocardial infarction, the volume of extravascular fluid increases in the lungs while the intravascular volume decreases. A hemoconcentration developed with increased hematocrit and a fall in plasma volume. The thrombocyte count fell continuously during the first 4 hours after the infarction. The CPK activity in the region of the myocardial infarct was reduced in comparison to uninfarcted tissues. Intravenous injection of 50,000 KIU/kg Trasylol within 20 minutes after the infaction caused a significant reduction of the extravascular fluid in the lungs. All the other parameters were not changed by Trasylol administration, with the possible exception of the fall in thrombocytes which seemed to be slowed after Trasylol.
我们的实验表明，在实验性心肌梗死后的早期阶段，猫的肺血管外液体积增加，而血管内容积减少。出现血液浓缩，血细胞比容增加，血浆量下降。梗死发生后的最初4小时内，血小板计数持续下降。与未梗死组织相比，心肌梗死区域的CPK活性降低。梗死发生后20分钟内静脉注射50,000 KIU/kg抑肽酶可使肺血管外液显著减少。除血小板数量下降可能减缓外，抑肽酶给药对所有其他参数均无影响，抑肽酶似乎使血小板数量下降减缓。
