Verongamine, a novel bromotyrosine-derived histamine H3-antagonist from the marine sponge Verongula gigantea.
作者信息
Mierzwa R, King A, Conover M A, Tozzi S, Puar M S, Patel M, Coval S J, Pomponi S A
机构信息
Schering Plough Research Institute, Kenilworth, New Jersey 07033.
出版信息
J Nat Prod. 1994 Jan;57(1):175-7. doi: 10.1021/np50103a029.
PMID:8158162
Abstract
The novel bromotyrosine derivative verongamine [1] has been isolated from the marine sponge Verongula gigantea. The isolation of verongamine was facilitated by employing histamine-H3 bioassay-guided fractionation. Verongamine is a specific histamine-H3 antagonist at concentrations as low as 1 microgram/ml.
摘要
Zotero 插件