Wasi C, Chaiprasithikul P, Auewarakul P, Puthavathana P, Thongcharoen P, Trishnananda M
Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Southeast Asian J Trop Med Public Health. 1993 Sep;24(3):461-6.
During August 1988 to January 1990, the immunogenicity and safety of purified chick embryo cell rabies vaccine (PCEC) given by the conventional and abbreviated regimens in 82 vaccinees moderately to severely exposed to laboratory proven rabid animals were studied. The 16 vaccinees received PCEC six doses as conventional schedule on days 0, 3, 7, 14, 28 and 90, the 11 vaccinees received six doses of PCEC plus human rabies immune globulin (HRIG) on day 0. The 29 vaccinees received an abbreviated schedule of PCEC as two doses on day 0, one dose each on days 7 and 21 and the 26 cases received PCEC abbreviated schedule plus HRIG on day 0. The kinetics of the neutralizing antibodies on days 0, 7, 14, 28, 56, 180 and 365 were studied for comparative purpose. All vaccinees had high antibody levels from day 14 which last longer than a year and were safe after one year follow up. The adverse reactions of the vaccine were mild and self-limited.
1988年8月至1990年1月，对82名中度至重度暴露于经实验室证实的狂犬病动物的接种者，研究了按常规和简化方案接种纯化鸡胚细胞狂犬病疫苗（PCEC）的免疫原性和安全性。16名接种者按常规程序在第0、3、7、14、28和90天接种6剂PCEC；11名接种者在第0天接种6剂PCEC加人狂犬病免疫球蛋白（HRIG）。29名接种者按简化程序在第0天接种2剂PCEC，在第7天和第21天各接种1剂；26名接种者在第0天接种简化程序的PCEC加HRIG。为作比较，研究了第0、7、14、28、56、180和365天中和抗体的动力学情况。所有接种者从第14天起抗体水平较高，持续时间超过一年，且经过一年随访均安全。该疫苗的不良反应轻微且为自限性。
