Tenorio A, Jindrak K, Weiner M, Bella E, Enquist I F
Surg Gynecol Obstet. 1976 Apr;142(4):537-43.
The effect of a standardized infection of pure and mixed cultures of gram-negative bacteria and a gram-positive coccus was studied in laparotomy wounds of rats. The infections were significantly stronger than in the control group wounds in 14 of 15 comparisons. This increased strength could not be correlated with an increased wound content of collagen. Results of histologic studies showed a vigorous inflammatory response which probably was responsible for the increased strength. There was a suggestion in our data to support the concept that certain bacteria evoke the proper inflammatory response to result in stronger wounds, while others provoke too little or too much inflammation.
在大鼠剖腹手术伤口中研究了革兰氏阴性菌纯培养物、混合培养物以及革兰氏阳性球菌的标准化感染的影响。在15次比较中的14次中，感染明显强于对照组伤口。这种增强的强度与伤口中胶原蛋白含量的增加无关。组织学研究结果显示出强烈的炎症反应，这可能是强度增加的原因。我们的数据表明支持这样一种概念，即某些细菌引发适当的炎症反应从而导致伤口更强壮，而其他细菌引发的炎症过少或过多。
