Levkut M, Plank L, Levkutova M, Konrád V
Department of Pathological Anatomy, University of Veterinary Medicine, Kosice, Slovakia.
Vet Immunol Immunopathol. 1994 Feb;40(2):163-70. doi: 10.1016/0165-2427(94)90031-0.
Prescapular lymph nodes from 109 cows seropositive to bovine leukemia virus (BLV) were examined for the presence of light chains of bovine immunoglobulin (Ig) kappa or lambda. A variety of reactions were present in prescapular lymph nodes, including B-zonal hyperplasia (23 cases, 21.1%), T-zonal hyperplasia (52 cases, 47.7%), mixed hyperplasia (18 cases, 16.5%), pulp proliferation (six cases, 5.5%), and atrophy (ten cases, 9.2%). In the case of pulp proliferation the immunohistological examination identified only Ig of a single light chain type lambda. The possible relationship of a monoclonal expression of Ig and development of tumorous proliferation is discussed in the study.
对109头牛白血病病毒（BLV）血清阳性奶牛的肩胛前淋巴结进行检查，以确定牛免疫球蛋白（Ig）κ或λ轻链的存在情况。肩胛前淋巴结出现了多种反应，包括B区增生（23例，21.1%）、T区增生（52例，47.7%）、混合增生（18例，16.5%）、髓质增生（6例，5.5%）和萎缩（10例，9.2%）。在髓质增生的病例中，免疫组织学检查仅发现了单一轻链类型λ的Ig。该研究讨论了Ig单克隆表达与肿瘤性增殖发展之间的可能关系。
