Odom J V, Nork T M, Schroeder B M, Cavender S A, van Slycken S, Leys M
Department of Ophthalmology, West Virginia University Health Sciences Center, Morgantown 26506.
Vision Res. 1994 Mar;34(6):829-37. doi: 10.1016/0042-6989(94)90220-8.
In three separate experiments albino rabbits, pigmented rabbits, and humans were tested following administration of acetazolamide and without acetazolamide. In all three experiments, we recorded electroretinograms (ERGs) under dark adapted and light adapted conditions and measured the b-wave amplitudes. Dark adapted ERG b-wave amplitudes were increased following administration of acetazolamide as compared to control conditions, in albino rabbits, pigmented rabbits and humans. Light adapted b-wave amplitudes showed no statistically significant changes as a function of acetazolamide administration although in all three experiments there was a trend toward light adapted b-wave amplitude reduction following administration of acetazolamide. In the human experiments, ERG a-wave amplitudes were also measured. Light adapted a-wave amplitudes were reduced following administration of acetazolamide. In the human experiments, several behavioral tests were performed, including L'Anthony desaturated D-15, Farnsworth-Munsell 100 hue, Cogan-Gunkel chromatograph, Nagel anomaloscope, Goldmann-Weekers dark adaptometry. There were no consistent changes in the human dark adaptation thresholds or color discrimination, although several measures approached significance.
在三个独立的实验中，对白化兔、有色兔和人类在服用乙酰唑胺和未服用乙酰唑胺的情况下进行了测试。在所有三个实验中，我们在暗适应和明适应条件下记录了视网膜电图（ERG），并测量了b波振幅。与对照条件相比，在白化兔、有色兔和人类中，服用乙酰唑胺后暗适应ERG的b波振幅增加。尽管在所有三个实验中都有服用乙酰唑胺后明适应b波振幅降低的趋势，但明适应b波振幅作为乙酰唑胺给药的函数没有显示出统计学上的显著变化。在人体实验中，还测量了ERG的a波振幅。服用乙酰唑胺后明适应a波振幅降低。在人体实验中，进行了多项行为测试，包括L'Anthony不饱和D-15、Farnsworth-Munsell 100色调、Cogan-Gunkel色谱仪、Nagel色盲检查镜、Goldmann-Weekers暗适应测量。尽管有几项测量接近显著水平，但人类暗适应阈值或颜色辨别能力没有一致的变化。
