Orefice G, Carrieri P B, Troisi E, Chirianni A, Maiorino A, Nolfe G, Rubino S, Coppola M, Campanella G
Department of Neurology, Medical School, Federico II, University of Naples.
Acta Neurol (Napoli). 1993 Dec;15(6):409-15.
We studied one hundred and six neurologically asymptomatic HIV-1-seropositive patients, mostly drug abusers, in various stages of HIV-1 infection to evaluate the frequency of three primitive reflexes: snout, palmomental, and glabellar. We also examined one hundred HIV-1-seronegative drug abusers and one hundred healthy heterosexual individuals. We observed the presence of one or more primitive reflexes in 41% of HIV-1-seropositive subjects, in 8% of HIV-1-seronegative drug abusers and in 3% of healthy individuals. We elicited more than one primitive reflex in 22% of patients, but never among the subjects of the two control groups. The associations of multiple reflexes were significantly more frequent in the most severe CDC stages. Our observations suggest that including evaluation of primitive reflexes in a standard neurologic examination may be useful in screening for early non specific cerebral dysfunction in neurologically asymptomatic HIV-1-seropositive subjects.
我们研究了106例神经学上无症状的HIV-1血清阳性患者，他们大多为药物滥用者，处于HIV-1感染的不同阶段，以评估三种原始反射的出现频率：噘嘴反射、掌颏反射和眉间反射。我们还检查了100例HIV-1血清阴性的药物滥用者和100名健康异性恋个体。我们观察到，41%的HIV-1血清阳性受试者、8%的HIV-1血清阴性药物滥用者和3%的健康个体存在一种或多种原始反射。22%的患者引出了不止一种原始反射，但在两个对照组的受试者中从未出现过。在疾病控制中心（CDC）最严重的阶段，多种反射的关联明显更为频繁。我们的观察结果表明，在标准神经学检查中纳入原始反射评估，可能有助于筛查神经学上无症状的HIV-1血清阳性受试者的早期非特异性脑功能障碍。
