Slagel D D, Lager D J, Dick F R
Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City.
Am J Clin Pathol. 1994 Apr;101(4):429-31. doi: 10.1093/ajcp/101.4.429.
The authors have observed discrete, densely basophilic inclusions in the peripheral blood neutrophils of 10 patients with acquired immunodeficiency syndrome (AIDS) and two additional patients without documented evidence of human immunodeficiency virus seropositivity. These inclusions were seen in 3 of 25 (12%) patients with AIDS in a retrospective review. Gram, periodic acid-Schiff, and Gomori methenamine silver stains failed to demonstrate staining of these bodies; however, the Feulgen reaction was positive. The inclusions may represent "apoptotic" nuclear fragments and thus may be similar to Howell-Jolly bodies of normoblasts in abnormal erythropoiesis. An association of these inclusions with nucleoside analogue antiviral therapy is indicated. These inclusions must be differentiated from intracytoplasmic infectious agents, Döhle bodies, and inclusions of inherited disorders.
作者在10例获得性免疫缺陷综合征（AIDS）患者以及另外2例无人类免疫缺陷病毒血清学阳性记录证据的患者的外周血中性粒细胞中观察到离散的、嗜碱性致密包涵体。在一项回顾性研究中，25例AIDS患者中有3例（12%）出现了这些包涵体。革兰氏染色、过碘酸希夫染色和戈莫里六胺银染色均未能显示这些小体的染色；然而，福尔根反应呈阳性。这些包涵体可能代表“凋亡”核碎片，因此可能类似于异常红细胞生成中幼红细胞的豪-焦小体。提示这些包涵体与核苷类似物抗病毒治疗有关。这些包涵体必须与胞质内感染因子、杜勒小体和遗传性疾病的包涵体相鉴别。
