Friedman H D, Inman D A, Hutchison R E, Poiesz B J
Department of Pathology and Laboratory Medicine, Department of Veterans Affairs Medical Center, Syracuse, New York 13210.
Am J Clin Pathol. 1994 Apr;101(4):432-7. doi: 10.1093/ajcp/101.4.432.
Thymoma is associated with benign and neoplastic diseases. The authors report the concurrence of invasive thymoma and T-lymphoblastic leukemia/lymphoma in a 95-year-old man. The hematologic malignancy was suspected terminally, whereas the thymoma was discovered at necropsy. The lymphoblastic leukemia/lymphoma had a clonally rearranged T-cell receptor beta-chain gene and a mature thymocyte immunophenotype. No retroviral gene sequences (human immunodeficiency virus 1 and 2, and human T-cell leukemia virus 1 and 2) were identified by polymerase chain reaction and hybridization analysis. The association of thymoma with hematologic neoplasm is reviewed.
胸腺瘤与良性和肿瘤性疾病相关。作者报告了一名95岁男性同时患有侵袭性胸腺瘤和T淋巴细胞母细胞白血病/淋巴瘤。血液系统恶性肿瘤在晚期被怀疑，而胸腺瘤是在尸检时发现的。淋巴细胞母细胞白血病/淋巴瘤具有克隆性重排的T细胞受体β链基因和成熟胸腺细胞免疫表型。通过聚合酶链反应和杂交分析未鉴定出逆转录病毒基因序列（人类免疫缺陷病毒1和2，以及人类T细胞白血病病毒1和2）。本文对胸腺瘤与血液系统肿瘤的关联进行了综述。
