Sawai T, Yoshimoto M, Kinoshita E, Baba T, Matsumoto T, Tsuji Y, Fukuda S, Harada N, Niikawa N
Department of Pediatrics, Nagasaki University, School of Medicine, Japan.
Am J Med Genet. 1994 Feb 15;49(4):428-30. doi: 10.1002/ajmg.1320490415.
We describe whole-body chimerism in a newborn infant with small phallus, pseudo-vaginal perineal hypospadias, and a bifid scrotum containing gonads. The human testis determining factor gene (SRY) was detected by PCR amplification. GTG-banding chromosome analysis in peripheral blood lymphocytes and cultured fibroblasts derived from right cubital skin showed a 46,XX/47,XY, +21 karyotype. Their ratios in each cell line were 294:5 and 178:7, respectively. QFQ-banding chromosome analysis documented 3 heteromorphic satellites on trisomic chromosomes 21 in the 47,XY, +21 cell line and a homozygous satellite pattern in the 46,XX cell line. Heteromorphic patterns of chromosomes 4, 13, 14, and 22 were also different between the two cell lines. To our knowledge, such disomy/trisomy chimeras have not been described previously.
