Honda H, Koiwa Y, Takagi K, Kikuchi J, Hoshi N, Takishima T, Butler J P
First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Am J Physiol. 1994 Mar;266(3 Pt 2):H881-90. doi: 10.1152/ajpheart.1994.266.3.H881.
We examined Advani and Lee's equation (ALeq) and a dimension analysis-derived equation (DAeq), both of which treat vibration of the elastic spherical shell and are able to estimate elasticity of the shell noninvasively when the sizes and eigen-frequency are provided. We confirmed that ALeq was numerically identical to DAeq and that both equations gave the precise elasticity of the silicone shell. Then we estimated left ventricular (LV) myocardial elasticity noninvasively at the moment of the first heart sound emission (1HS) in 25 healthy subjects and 14 hypertrophic cardiomyopathy (HCM) patients, based on the LV eigen-frequency detected by an intraesophageal miniature vibration sensor. HCM patients had a higher mean value of LV myocardial elasticity at 1HS than healthy subjects [102.3 +/- 33.4 vs. 70.7 +/- 24.4 kPa, P < 0.01 (Pa = N/m2 = 10 dyn/cm2)]. We thereby demonstrated the possibility of a noninvasive estimate of myocardial elasticity.
我们研究了阿德瓦尼和李的方程（ALeq）以及一个基于量纲分析得出的方程（DAeq），这两个方程均涉及弹性球壳的振动，并且在已知尺寸和固有频率的情况下能够无创地估计球壳的弹性。我们证实ALeq在数值上与DAeq相同，并且这两个方程都能给出硅胶壳精确的弹性值。然后，我们基于经食管微型振动传感器检测到的左心室（LV）固有频率，对25名健康受试者和14名肥厚型心肌病（HCM）患者在第一心音（1HS）发出瞬间的左心室心肌弹性进行了无创估计。HCM患者在1HS时左心室心肌弹性的平均值高于健康受试者[102.3±33.4 vs. 70.7±24.4 kPa，P<0.01（Pa = N/m2 = 10 dyn/cm2）]。由此我们证明了无创估计心肌弹性的可能性。
