多发性硬化症中针对凝血因子IX和VIII的循环IgG抗体
Circulating IgG antibodies against factors IX and VIII in multiple sclerosis.
作者信息
Moake J L, Kent C J, Meta L D, Wright L C
出版信息
Acta Haematol. 1976;55(1):53-9. doi: 10.1159/000207993.
A 64-year-old man with multiple sclerosis developed a circulating anticoagulant. Three immunoglobulin fractions (I = IgG; II =IgG+IgA; III = IgM) were separated from patient serum by 33-percent ammonium sulfate precipitation and DEAE-52 cellulose column chromatography. Fractions I (IgG) and II (IgG+IgA) had factor VIII inhibitory activity on incubation. Fraction I (IgG) possessed, in addition, immediate anti-IX activity which did not require incubation. Absorption studies characterized the VIII inhibitors as IgG-gamma in fraction I and IgG-gamma+IgG-lambda in fraction II. Immediately reactive IgG anti-IX antibodies associated with kinetically distinct IgG anti-VIII antibodies have not been described previously.
一名患有多发性硬化症的64岁男性出现了循环抗凝物质。通过33%硫酸铵沉淀和DEAE - 52纤维素柱色谱法从患者血清中分离出三种免疫球蛋白组分（I = IgG；II = IgG + IgA；III = IgM）。组分I（IgG）和II（IgG + IgA）在孵育时具有因子VIII抑制活性。此外，组分I（IgG）具有无需孵育的即刻抗IX活性。吸收研究表明，组分I中的VIII抑制剂为IgG - γ，组分II中的为IgG - γ + IgG - λ。此前尚未描述过与动力学上不同的IgG抗VIII抗体相关的即刻反应性IgG抗IX抗体。
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