Jeannet M, Bloch A, Dayer J M, Farquet J J, Girard J P, Cruchaud A
Acta Haematol. 1976;55(2):109-117. doi: 10.1159/000208002.
A patient with renal disease developed Coombs-positive hemolytic anemia while receiving cephalothin therapy. An anti-cephalothin IgG antibody was detected in the patient's serum and in the eluates from her erythrocytes. In addition, nonimmunologic binding of normal and patient's serum proteins to her own and cephalothin-coated normal red cells was demonstrated. Skin tests and in vitro lymphocyte stimulation revealed that the patient was sensitized to cephalothin and also to ampicillin. Careful investigation of drug-induced hemolytic anemias reveals the complexity of the immune mechanisms involved.
一名肾病患者在接受头孢噻吩治疗时发生了库姆斯阳性溶血性贫血。在患者血清及红细胞洗脱液中检测到了抗头孢噻吩IgG抗体。此外，还证实了正常血清蛋白和患者血清蛋白与她自身及头孢噻吩包被的正常红细胞存在非免疫性结合。皮肤试验和体外淋巴细胞刺激试验显示，该患者对头孢噻吩以及氨苄西林均过敏。对药物性溶血性贫血的仔细研究揭示了其中涉及的免疫机制的复杂性。
