[橄榄体脑桥小脑萎缩与帕金森病：诊断问题]

[Olivopontocerebellar atrophy and Parkinson's disease: diagnostic problems].

作者信息

Rodríguez M, Artieda J, Zubieta J L, Obeso J A

机构信息

Departamento de Neurología, Universidad de Navarra, Pamplona.

出版信息

Neurologia. 1994 Jan;9(1):4-11.

PMID:8161468

Abstract

Clinical diagnoses of Parkinson's disease (PD) is highly inaccurate. Olivopontocerebellar atrophy (OPCA) is a major source of diagnostic confusion. We have studied the clinical characteristics of 50 patients with PD, 24 patients with OPCA judged by the presence of selective atrophy of the cerebellum and brainstem (diagnosed by CT brain scan) and 30 normal controls of similar age. The typical triad of PD, tremor, rigidity and akinesia, did not distinguish among patients from either group. The presence of severe postural imbalance and reflex myoclonus (in OPCA but not in PD) were the 2 most highly discriminative clinical features.

摘要

帕金森病（PD）的临床诊断准确性极低。橄榄体脑桥小脑萎缩（OPCA）是造成诊断混淆的主要原因。我们研究了50例帕金森病患者、24例经小脑和脑干选择性萎缩（通过脑部CT扫描诊断）判定为OPCA的患者以及30名年龄相仿的正常对照者的临床特征。帕金森病典型的三联征，即震颤、强直和运动不能，无法区分这两组患者。严重姿势性失衡和反射性肌阵挛（存在于OPCA患者而非帕金森病患者中）是两个最具鉴别性的临床特征。