Prat J, Pujol M, Girona V, Muñoz M, Solé L A
Unitat de Físico-Química, Facultat de Farmacia, Barcelona, Spain.
J Pharm Biomed Anal. 1994 Jan;12(1):81-4. doi: 10.1016/0731-7085(94)80013-8.
The degradation of carboplatin (3.2 mg ml-1) in 5% glucose infusion solution at 25 degrees C and protected from light was investigated. The effects of the material of the container and temperature were also studied. Solutions were prepared in 5% glucose solution and stored in glass bottles, polyethylene (PE) and polypropylene (PP) containers at 40, 50 and 60 degrees C and at 25 degrees C +/- 1 degrees C. Samples were assayed by an HPLC method to determine the residual carboplatin concentration at each time of sampling. Carboplatin degradation followed pseudo-first-order kinetics and no dependence on the nature of the container was found. After 1 month at 25 degrees (+/- 1 degrees)C the change in carboplatin concentration was < 2% of the initial concentration in 5% glucose. These results are in agreement with those predicted by the application of the Arrhenius equation.
研究了卡铂（3.2毫克/毫升）在25℃下于5%葡萄糖输液中避光保存时的降解情况。同时还研究了容器材质和温度的影响。将溶液配制于5%葡萄糖溶液中，并分别储存在玻璃瓶、聚乙烯（PE）瓶和聚丙烯（PP）瓶中，温度设置为40℃、50℃和60℃以及25℃±1℃。通过高效液相色谱法（HPLC）对样品进行分析，以测定每次取样时卡铂的残留浓度。卡铂降解遵循准一级动力学，且未发现其降解与容器性质有关。在25℃（±1℃）下放置1个月后，5%葡萄糖中卡铂浓度的变化小于初始浓度的2%。这些结果与应用阿伦尼乌斯方程预测的结果一致。
