评估新型抗疟药物对恒河猴体内由滋养体诱导的食蟹猴疟原虫疟疾的疗效。
Evaluating new antimalarial drugs against trophozoite induced Plasmodium cynomolgi malaria in rhesus monkeys.
作者信息
Davidson D E, Johnsen D O, Tanticharoenyos P, Hickman R L, Kinnamon K E
出版信息
Am J Trop Med Hyg. 1976 Jan;25(1):26-33. doi: 10.4269/ajtmh.1976.25.26.
PMID:816211
Abstract
An antimalarial drug testing system is described which utilizes trophozoite induced Plasmodium cynomolgi malaria in rhesus monkeys. The schizonticidal activity of standard antimalarial drugs in this system is reported. The system accurately predicted antimalarial activity in man of 8 of 9 compounds selected for clinical trials.
摘要
描述了一种抗疟药物测试系统，该系统利用食蟹猴疟原虫滋养体诱导的恒河猴疟疾。报告了标准抗疟药物在该系统中的裂殖体杀灭活性。该系统准确预测了9种入选临床试验的化合物中8种在人体中的抗疟活性。
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