Wong M M, Lim K C
Am J Trop Med Hyg. 1976 Jan;25(1):94-8.
In this third of a series of studies on experimental dirofilariasis in primate hosts, 3 Macaca cynomolgus, 6 M. speciosa, and 2 M. mulatta were inoculated with infective larvae of Dirofilaria tenuis, a parasite of the raccoon, and were killed at periods ranging from 2 weeks to 13 months of infection. One M. mulatta and one M. speciosa were treated daily with prednisolone beginning 2 months after inoculation; worms were recovered from these and 5 other monkeys (7 of 11). Microfilaremia was detected during the 28th week of infection in a monkey under prednisolone treatment. Microfilaremia was found to be aperiodic in that monkey and in a raccoon. Eosinophilia and antibodies to the microfilaria reached appreciable levels in three monkeys harboring gravid worms. Development of D. tenuis in M. speciosa appeared to be comparable to that observed in man.
在关于灵长类宿主实验性犬恶丝虫病的系列研究的第三部分中，给3只食蟹猴、6只熊猴和2只恒河猴接种了浣熊寄生虫——细薄恶丝虫的感染性幼虫，并在感染后2周龄至13月龄期间将它们处死。1只恒河猴和1只熊猴在接种后2个月开始每天用泼尼松龙治疗；从这些猴子以及另外5只猴子（11只中的7只）体内获取了虫体。在接受泼尼松龙治疗的1只猴子感染后第28周检测到微丝蚴血症。在那只猴子和1只浣熊体内发现微丝蚴血症是无规律的。在3只怀有成熟虫体的猴子中，嗜酸性粒细胞增多以及针对微丝蚴的抗体达到了相当水平。熊猴体内细薄恶丝虫的发育情况似乎与人身上观察到的情况相似
