King C L, Nutman T B
Division of Geographic Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Infect Agents Dis. 1993 Apr;2(2):103-8.
Infection with tissue-invasive helminth infections characteristically induces immunological responses associated with immediate hypersensitivity such as IgE elevations, tissue and peripheral blood eosinophilia, and mast cell hyperplasia. Specific sets of cytokines appear to regulate these responses; the resulting responses reflect the balance of upregulatory and inhibitory signals these cytokines provide. The nature of these cytokines and their role in both protective immunity and pathogenesis in helminth infections of humans is the subject of this review.
组织侵袭性蠕虫感染通常会引发与速发型超敏反应相关的免疫反应，如IgE升高、组织和外周血嗜酸性粒细胞增多以及肥大细胞增生。特定的细胞因子组合似乎调节这些反应；所产生的反应反映了这些细胞因子提供的上调和抑制信号之间的平衡。这些细胞因子的性质及其在人类蠕虫感染的保护性免疫和发病机制中的作用是本综述的主题。
