Logar D, Rozman B, Vizjak A, Ferluga D, Mulder A H, Kallenberg C G
University Medical Centre, Department of Rheumatology, Ljubljana, Slovenia.
Br J Rheumatol. 1994 Feb;33(2):167-9. doi: 10.1093/rheumatology/33.2.167.
We report a 32-yr-old woman who suffered a stroke as a consequence of arteritis of both internal carotid arteries confirmed by selective carotid arteriography. Laryngeal inflammation and kidney biopsy proven focal crescentic glomerulonephritis were also present in this patient. Anti-neutrophil cytoplasmic autoantibodies with specificity for proteinase 3 were detected in high titre during the active phase of the disease. This overlap syndrome with features indicating both Takayasu's arteritis and Wegener's granulomatosis suggests a common pathogenesis for these diseases.
我们报告了一名32岁女性，她因选择性颈动脉造影证实的双侧颈内动脉动脉炎而中风。该患者还存在喉部炎症以及经肾脏活检证实的局灶性新月体性肾小球肾炎。在疾病活动期检测到高滴度的抗蛋白酶3特异性抗中性粒细胞胞浆自身抗体。这种具有提示高安动脉炎和韦格纳肉芽肿特征的重叠综合征提示这些疾病存在共同的发病机制。
