Levine S, Saltzman A
Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.
Exp Mol Pathol. 1994 Feb;60(1):60-9. doi: 10.1006/exmp.1994.1006.
During the healing phase of a chemical peritonitis, one or several skeletal muscle fibers develop, de novo, in the peritoneum of the adult of weanling rat diaphragm. One week after the initial injury the new muscle fibers are narrow and have central nuclei and cross-striations. The fibers increase progressively in caliber and the nuclei take up a subsarcolemmal location. The newly formed muscle fibers are separated from the intrinsic diaphragmatic muscle by an elastic membrane and by a hand of hyaline connective tissue. They are separated from the peritoneal surface by a zone of granulation tissue. Most new fibers are oriented at right angles to the intrinsic diaphragmatic muscle fibers. Their location and orientation suggest an origin from mesothelium or from fibroblasts in the granulation tissue rather than from the intrinsic diaphragmatic muscle. A similar phenomenon can be induced in the pleura on the other side of the diaphragm. In contrast, damage to the diaphragmatic muscle by injection of aluminum lactate does not engender myogenesis in the location described despite active regeneration in the intrinsic muscle.
在化学性腹膜炎的愈合阶段，成年断奶大鼠膈肌的腹膜中会重新长出一条或几条骨骼肌纤维。初次损伤一周后，新的肌纤维很细，有中央核和横纹。纤维直径逐渐增加，核占据肌膜下位置。新形成的肌纤维通过弹性膜和一层透明结缔组织与膈肌固有肌分开。它们通过肉芽组织区域与腹膜表面分开。大多数新纤维与膈肌固有肌纤维成直角排列。它们的位置和排列表明其起源于间皮或肉芽组织中的成纤维细胞，而非膈肌固有肌。在膈肌另一侧的胸膜中也可诱发类似现象。相比之下，注射乳酸铝对膈肌造成损伤后，尽管固有肌有活跃的再生，但在上述位置不会发生肌生成。
