Chipps B E, Talamo R C, Mellits E D, Valentine M D
Ann Allergy. 1978 Oct;41(4):211-5.
Immediate (IgE-mediated) skin tests are widely used in the diagnosis of allergic diseases. Skin tests correlate well with more specialized studies (RAST, histamine release and provocation tests) in the diagnosis of allergic disease. Lack of standardization and quantitation of biologic potency of allergens make critical comparison of skin test results impossible. A survey of practicing allergists yielded widely divergent opinions concerning the effect of anti-allergic drugs on skin tests. The results of published studies indicate that only antihistamines cause significant depression of skin reactivity. Therefore, therapy for asthma may be continued while diagnostic skin testing is in progress, avoiding the possible morbidity associated with discontinuing pharmacologic therapy.
即时（IgE介导）皮肤试验广泛应用于过敏性疾病的诊断。在过敏性疾病的诊断中，皮肤试验与更专业的研究（放射变应原吸附试验、组胺释放试验和激发试验）相关性良好。变应原生物效价缺乏标准化和定量使得皮肤试验结果的关键比较无法进行。一项针对执业过敏症专科医生的调查得出了关于抗过敏药物对皮肤试验影响的广泛不同意见。已发表研究的结果表明，只有抗组胺药会导致皮肤反应性显著降低。因此，在进行诊断性皮肤试验时，哮喘治疗可以继续，避免因停止药物治疗而可能出现的发病率。
