Kavsan V M, Koval A P
Institute of Molecular Biology and Genetics, Ukrainian Academy of Sciences, Kiev.
Gene. 1994 Apr 20;141(2):301-2. doi: 10.1016/0378-1119(94)90590-8.
Representatives of the fish family Salmonidae were reported to possess two nonallelic growth hormone (GH)-encoding genes. In addition to those, we found a third GH-like sequence in a chum salmon genomic DNA library. A number of point mutations and large deletions abolished the possibility of expressing this sequence, showing that the chum salmon genomic DNA contains a GH pseudogene besides functional GH genes.
据报道,鲑科鱼类的代表拥有两个非等位的生长激素(GH)编码基因。除此之外,我们在银大麻哈鱼基因组DNA文库中发现了第三个类GH序列。大量的点突变和大片段缺失消除了该序列表达的可能性,这表明银大麻哈鱼基因组DNA除了功能性GH基因外还包含一个GH假基因。