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经胸段食管裂孔内脏神经切除术对胰腺癌疼痛的镇痛效果。基于51例手术治疗的癌症病例

[Analgesic effect of transhiatal splanchnectomy in pain from cancer of the pancreas. Apropos of 51 operated cancers].

作者信息

Sielezneff I, Sastre B, Crespy B, Carabalona B, Delpero J R, Michotey G

机构信息

Service de Chirurgie Générale et Digestive, Hôpital Sainte-Marguerite, Marseille.

出版信息

J Chir (Paris). 1993 Nov;130(11):447-52.

PMID:8163598
Abstract

The greater splanchnic nerves are responsible for sympathetic innervation of the supra mesocolic viscera, and total bilateral neurotomy is efficient to relieve pancreatic pain. Their dissection is easy by a midline transperitoneal route used for pancreatic cancer surgery. The aim of this study was to evaluate the pain relief related to transhiatal bilateral splanchnicotomy in patients with pancreatic cancer. The tumor was unresectable for all the patients, and nobody was operated only to make neurotomy. Twenty two patients had single bilateral splanchnicotomy, and other had an associated biliary and/or digestive diversion. There was not postoperative specific mortality, and postoperative mortality rate was 3.9%. Specific postoperative morbidity rate was 6%. Most of the patients (83.3%) had immediate pain relief, with or without diversion (respectively 80.7% and 86.3%, p = 0.6). Our data suggest that pain recurs for some patients three months after surgery (pain control in respectively 69.2% and 72.7%), but difference was not significant (p = 0.14). Our results demonstrate that transhiatal bilateral splanchnicotomy relieves pain in patients with pancreatic cancer, with a poor specific morbidity.

摘要

内脏大神经负责结肠上区内脏的交感神经支配,双侧完全神经切断术能有效缓解胰腺疼痛。通过用于胰腺癌手术的中线经腹途径很容易进行其解剖。本研究的目的是评估经裂孔双侧内脏神经切断术对胰腺癌患者疼痛缓解的效果。所有患者的肿瘤均无法切除,且没有人仅为了进行神经切断术而接受手术。22例患者接受了单纯双侧内脏神经切断术,其他患者则同时进行了胆道和/或消化道改道手术。术后无特异性死亡,术后死亡率为3.9%。特异性术后发病率为6%。大多数患者(83.3%)立即缓解了疼痛,无论是否进行改道手术(分别为80.7%和86.3%,p = 0.6)。我们的数据表明,一些患者在术后三个月疼痛复发(疼痛控制率分别为69.2%和72.7%),但差异不显著(p = 0.14)。我们的结果表明,经裂孔双侧内脏神经切断术可缓解胰腺癌患者的疼痛,特异性发病率较低。

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