Kimura M, Arai H, Takahashi T, Iwamoto N
Department of Psychiatry, Juntendo University School of Medicine, Saitama, Japan.
J Neurol. 1994 Jan;241(3):170-4. doi: 10.1007/BF00868345.
An immunohistochemical study using the mirror-image technique was performed in order to establish whether amyloid P component is involved in the mechanism of deposition of amyloid fibrils in senile plaques (SPs) in Alzheimer-type dementia (ATD). Ninety percent of beta/A4 protein-immunoreactive SPs were also stained by the anti-amyloid P component immunohistochemistry, and this applied to all of the diffuse, primitive and classical types of beta/A4 deposits. These findings may suggest an involvement of amyloid P component in the formation of amyloid fibrils in senile plaques in ATD brains.
为确定淀粉样蛋白P成分是否参与阿尔茨海默型痴呆（ATD）患者老年斑（SPs）中淀粉样原纤维的沉积机制，采用镜像技术进行了一项免疫组织化学研究。90%的β/A4蛋白免疫反应性SPs也被抗淀粉样蛋白P成分免疫组织化学染色，这适用于所有弥漫性、原始性和经典型β/A4沉积物。这些发现可能提示淀粉样蛋白P成分参与了ATD脑内老年斑中淀粉样原纤维的形成。
