Williams R G, Richards S H, Mills R G, Eccles R
Department of Otolaryngology, University Hospital of Wales, United Kingdom.
Laryngoscope. 1994 Apr;104(4):484-7. doi: 10.1288/00005537-199404000-00015.
The fundamental frequency of 14 patients undergoing hypophysectomy was studied. Eight patients had acromegaly, 3 had a prolactinoma, and 3 had nonfunctioning adenomas. The fundamental frequency of 22 normal, healthy volunteers was measured for comparison. In addition, the external size of the larynx of all patients and volunteers was measured and a relationship between external laryngeal size and the mean fundamental frequency was identified in the volunteers. The mean fundamental frequency in patients with acromegaly was significantly lower than the other 6 patients undergoing hypophysectomy and, in addition, was also lower than the 22 normal volunteers. Postoperatively the fundamental frequency of the acromegalic patients increased rapidly to within the expected normal range. Patients with acromegaly have a lowered fundamental frequency which is most likely due to altered vocal cord mass and elasticity, which is a reversible change. Patients with acromegaly can expect a rapid and complete return of normal fundamental frequency within 2 weeks of surgery to remove the pituitary adenoma.
对14例接受垂体切除术的患者的基频进行了研究。其中8例患有肢端肥大症，3例患有催乳素瘤，3例患有无功能腺瘤。测量了22名正常健康志愿者的基频以作比较。此外，还测量了所有患者和志愿者的喉部外部尺寸，并在志愿者中确定了喉部外部尺寸与平均基频之间的关系。肢端肥大症患者的平均基频显著低于其他6例接受垂体切除术的患者，此外，也低于22名正常志愿者。术后，肢端肥大症患者的基频迅速上升至预期的正常范围内。肢端肥大症患者的基频降低，这很可能是由于声带质量和弹性改变所致，这是一种可逆性变化。肢端肥大症患者在切除垂体腺瘤手术后2周内有望迅速且完全恢复正常基频。
