Skłodowski P
Oddziału Neurologicznego W.S.Z. im. Kopernika, Lodzi.
Neurol Neurochir Pol. 1993 Nov-Dec;27(6):877-83.
The author reviews some important publications dealing with treatment of multiple sclerosis (m.s.) with the most commonly used immunosuppressive agents i.e. steroids and cyclophosphamide. He emphasises the methodology referring to group selection as well as placebo group and the way of the therapy results verification. The author concludes that many studies on the effective treatment with immunosuppressive agents are not sufficiently proved from the methodological point of view as well as the evaluation of the therapeutical effects in comparison with the placebo group is not convincing. The author appreciates the use of MRI in evaluation of the treatment effects. In the authors opinion the effectiveness of immunosuppressive therapy has not been so far sufficiently proved.
作者回顾了一些重要的出版物，这些出版物涉及使用最常用的免疫抑制剂（即类固醇和环磷酰胺）治疗多发性硬化症（MS）。他强调了关于组选择以及安慰剂组的方法学，以及治疗结果验证的方式。作者得出结论，从方法学角度来看，许多关于免疫抑制剂有效治疗的研究没有得到充分证明，并且与安慰剂组相比，治疗效果的评估也缺乏说服力。作者赞赏在评估治疗效果时使用磁共振成像（MRI）。在作者看来，免疫抑制疗法的有效性迄今尚未得到充分证明。
