Pate D S, Margolin D I
Cognitive Neuroscience Laboratory, Department of Veterans Affairs Medical Center, Fresno, CA.
Neurology. 1994 Apr;44(4):669-74. doi: 10.1212/wnl.44.4.669.
The contribution of cognitive slowing to the slowed performance of patients with Parkinson's disease (PD) is a matter of long-standing debate. In this study, we contrasted the performance of PD patients on two reaction-time tasks with the performance of Alzheimer's disease (AD) patients, young normal subjects, and elderly normal subjects. Both nondemented and demented PD patients showed cognitive as well as motor slowing, and the extent of cognitive slowing varied with overall cognitive status. Moreover, by comparison with the cognitive slowing in AD patients, cognitive slowing in PD patients was disproportionate to their general level of cognitive performance. We suggest that this disproportionality be used to differentiate the concepts of bradyphrenia and nonspecific cognitive slowing.
认知迟缓对帕金森病（PD）患者动作迟缓的影响一直是长期争论的话题。在本研究中，我们将PD患者在两项反应时间任务中的表现与阿尔茨海默病（AD）患者、年轻正常受试者和老年正常受试者的表现进行了对比。未患痴呆症和患痴呆症的PD患者均表现出认知和动作迟缓，且认知迟缓的程度随整体认知状态而变化。此外，与AD患者的认知迟缓相比，PD患者的认知迟缓与其总体认知表现水平不成比例。我们建议用这种不成比例来区分精神运动迟缓与非特异性认知迟缓的概念。
