Glosser G, Wolfe N, Kliner-Krenzel L, Albert M L
Department of Neurology, Graduate Hospital, Philadelphia, Pennsylvania 19146.
J Nerv Ment Dis. 1994 Aug;182(8):432-6. doi: 10.1097/00005053-199408000-00002.
Performance profiles of patients with different dementia syndromes (Alzheimer's disease and Parkinson's disease) were compared with each other and with those of neurologically impaired and healthy individuals without dementia on a new instrument for screening dementia, the Cross-Cultural Cognitive Examination (CCCE). The CCCE measures discriminated reliably between nondemented and demented patients, regardless of etiology. Comparisons between dementia groups found that dementia patients with Parkinson's disease (PD) showed more severe psychomotor slowing and depression, compared with patients with Alzheimer's disease, who showed more impaired recall of recently learned verbal information and verbal abstract reasoning. The CCCE also distinguished between the motor and affective symptoms that are common to all PD patients and the dementia symptoms that occur in some PD patients. These results provide further support for the clinical utility of the CCCE for discriminating dementia from normal cognitive functioning and for initial identification of different dementia syndromes.
在一种用于筛查痴呆症的新工具——跨文化认知检查（CCCE）上，对患有不同痴呆综合征（阿尔茨海默病和帕金森病）的患者的表现概况进行了相互比较，并与神经功能受损但无痴呆症的个体以及健康个体进行了比较。无论病因如何，CCCE的各项测量指标都能可靠地区分非痴呆患者和痴呆患者。痴呆症组之间的比较发现，与阿尔茨海默病患者相比，帕金森病（PD）痴呆患者表现出更严重的精神运动迟缓及抑郁，而阿尔茨海默病患者在近期所学言语信息的回忆及言语抽象推理方面受损更严重。CCCE还区分了所有PD患者共有的运动和情感症状以及部分PD患者出现的痴呆症状。这些结果为CCCE在区分痴呆与正常认知功能以及初步识别不同痴呆综合征方面的临床实用性提供了进一步支持。
