Jaffard R, Cardo B
C R Acad Hebd Seances Acad Sci D. 1976 Jan 12;282(2):207-9.
Specific response inhibition and generalized behavioral suppression (conditioned emotional response) contributions to a step-through passive avoidance performance are tested in two inbred strains of mice. For this purpose response contingent (0 sec.) and delayed punishment (from 5 to 60 sec.) are used in the learning session. The results of the test session (24 hr later) show that in the BALB/c strain, the response contingent component is very important (i.e. delaying the punishment produces a rapid decrease of the step-through latency). On the otherhand the latency remains unaffected in C57 BL/6 mice, showing that conditioned emotional response is the major determinant of the passive avoidance performance in this strain. These results might at least partially explain some contradictory results about memory differences between inbred strains of mice. Moreover they show that more sophisticated behavioral analysis is necessary whenever interstrain comparisons or genetic analysis are used for studying learning and memory.
在两个近交系小鼠中测试了特异性反应抑制和一般性行为抑制（条件性情绪反应）对穿梭箱被动回避行为表现的影响。为此，在学习阶段采用了反应即时（0秒）和延迟惩罚（5至60秒）。测试阶段（24小时后）的结果表明，在BALB/c品系中，反应即时成分非常重要（即延迟惩罚会使穿梭潜伏期迅速缩短）。另一方面，C57 BL/6小鼠的潜伏期不受影响，表明条件性情绪反应是该品系被动回避行为表现的主要决定因素。这些结果可能至少部分解释了关于近交系小鼠记忆差异的一些矛盾结果。此外，它们表明，每当使用品系间比较或基因分析来研究学习和记忆时，更复杂的行为分析是必要的。
