[腺病毒DNA在HeLa细胞感染开始时转移至细胞核]

[Transfer of adenovirus DNA into the nucleus at the beginning of infection of HeLa cells].

作者信息

Ogier G, Chardonnet Y, Cantepie-Auray J

出版信息

C R Acad Hebd Seances Acad Sci D. 1976 Jan 12;282(2):247-50.

Abstract

2 hrs after infection of HeLa cells with Ad 7, viral DNA was found in the nuclei. Inactivation of the virus with ultraviolet or antiserum, or pretreatment of the cells with chloroquine, did not affect the localisation of the DNA. The intranuclear DNA originated at least partly from viral particles passing through lysosomes. The appearance of Ad 7 DNA in the nucleus was delayed as compared to Ad 5 DNA.

摘要

用腺病毒7型感染HeLa细胞2小时后，在细胞核中发现了病毒DNA。用紫外线或抗血清使病毒失活，或用氯喹对细胞进行预处理，均不影响DNA的定位。细胞核内的DNA至少部分源自穿过溶酶体的病毒颗粒。与腺病毒5型DNA相比，腺病毒7型DNA在细胞核中的出现有所延迟。