Heldman A W, Goldschmidt-Clermont P J
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Symp Soc Exp Biol. 1993;47:317-24.
The actin cytoskeleton is a remarkably dynamic structure in non-muscle cells which responds to cell stimulation by a variety of cytokines. A paradigm for such cytokine-induced reorganization of the actin superstructure is the actin response to growth factor of the EGF/PDGF family. This paper reviews the role of the polyphosphoinositide-metabolism, small GTP-binding proteins and profilin in the reorganization of the actin cytoskeleton in cells activated by growth factors.
肌动蛋白细胞骨架在非肌肉细胞中是一种非常动态的结构，它会对多种细胞因子的细胞刺激做出反应。这种由细胞因子诱导的肌动蛋白超结构重组的一个范例是肌动蛋白对表皮生长因子/血小板衍生生长因子（EGF/PDGF）家族生长因子的反应。本文综述了多磷酸肌醇代谢、小GTP结合蛋白和丝切蛋白在生长因子激活的细胞中肌动蛋白细胞骨架重组中的作用。
