Matsubayashi K, Kimura H, Tabuchi A
Department of Ophthalmology, Kawasaki Medical School, Okayama-ken, Japan.
Nippon Ganka Gakkai Zasshi. 1994 Apr;98(4):404-7.
An examination was made on the mechanism of botulinum toxin injection into extraocular muscles with the use of the power spectrum. Four cases of esotropia (11-16 years) were treated with 0.5 to 3.25 units of botulinum toxin injected into the medical rectus muscle. After the injection, power spectral components under 300 Hz were decreased. In the case of repeated injections, the spectrum resembled the pattern of slow fiber components. It is assumed that a malfunction of fast fibers rather than slow ones is related to the effects of botulinum toxin on extraocular muscles.
利用功率谱对肉毒杆菌毒素注射到眼外肌的机制进行了研究。对4例内斜视患者（11 - 16岁），在其内侧直肌注射0.5至3.25单位的肉毒杆菌毒素进行治疗。注射后，300Hz以下的功率谱成分降低。在重复注射的情况下，频谱类似于慢肌纤维成分的模式。据推测，肉毒杆菌毒素对眼外肌的作用与快肌纤维而非慢肌纤维的功能障碍有关。
