Otto J J
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907-1392.
Curr Opin Cell Biol. 1994 Feb;6(1):105-9. doi: 10.1016/0955-0674(94)90123-6.
Recent studies have greatly expanded our understanding of actin-bundling proteins. A new group of actin-bundling proteins, the fascins, has been recognized. An actin-bundling protein inhibits actin depolymerization even under conditions in which it cannot produce a gel, which suggests that bundling proteins may affect actin filament dynamics. A villin-like protein is present in Dictyostelium, shedding doubt on current ideas on the evolution of villin. Domain mapping continues to be a major thrust of research into most groups of bundling proteins.
最近的研究极大地拓展了我们对肌动蛋白成束蛋白的理解。一组新的肌动蛋白成束蛋白，即丝束蛋白，已被识别出来。一种肌动蛋白成束蛋白即使在无法形成凝胶的条件下也能抑制肌动蛋白解聚，这表明成束蛋白可能会影响肌动蛋白丝的动力学。盘基网柄菌中存在一种类绒毛蛋白，这对目前关于绒毛蛋白进化的观点提出了质疑。结构域定位仍是大多数成束蛋白研究群体的主要研究方向。
