Joshi H C
Department of Anatomy and Cell Biology, Emory University School of Medicine, Atlanta, GA 30322.
Curr Opin Cell Biol. 1994 Feb;6(1):54-62. doi: 10.1016/0955-0674(94)90116-3.
The polar assembly of cellular microtubules is organized by microtubule organizing centers (MTOCs). Eukaryotic cells across different species, and different cell types within single species, have morphologically diverse MTOCs, which have the common function of organizing microtubule arrays by initiating microtubule assembly and anchoring microtubules by their slow-growing 'minus' ends, thus ensuring that the rapidly growing 'plus' ends extend distally. The past few years have witnessed a variety of approaches aimed at defining the molecular components of the MTOC that are responsible for regulating microtubule assembly by defining molecules common to all MTOCs.
细胞微管的极性组装由微管组织中心（MTOC）进行组织。不同物种的真核细胞以及单一物种内的不同细胞类型，都具有形态各异的MTOC，它们具有共同的功能，即通过启动微管组装并通过其生长缓慢的“负”端锚定微管来组织微管阵列，从而确保快速生长的“正”端向远端延伸。在过去几年中，出现了多种方法，旨在通过定义所有MTOC共有的分子来确定负责调节微管组装的MTOC的分子成分。
