Haussmann R, Polarz H, Rauch H, Graf B, Lang J, Fleischer F, Martin E, Saggau W
Department of Anesthesiology, University of Heidelberg, Germany.
J Cardiothorac Vasc Anesth. 1994 Feb;8(1):61-3. doi: 10.1016/1053-0770(94)90014-0.
Repeated induction of ventricular fibrillation (VF) with circulatory compromise during implantable cardioverter defibrillator (ICD) testing may cause cerebral injury. To test this hypothesis, somatosensory evoked potentials (SEP), a more sensitive marker of injury, were recorded in patients (N = 10) undergoing ICD implantation. SEP were recorded before induction of anesthesia, after induction of anesthesia, before and at several times following induction of VF. Possible modifying factors of the SEP measurements such as anesthetic application, blood pressure, body temperature, and hematocrit remained constant throughout the operations. Central conduction time was unaffected by ICD defibrillation testing. Amplitude of SEP primary complexes was transiently reduced at 34.9% (P < 0.01) by defibrillation testing, but returned to control within 10 minutes after testing. It is concluded that while ICD defibrillation testing may produce transient changes in SEP, there is no evidence of residual cerebral injury.
在植入式心脏复律除颤器（ICD）测试期间，反复诱发伴有循环功能障碍的心室颤动（VF）可能会导致脑损伤。为了验证这一假设，对接受ICD植入术的患者（N = 10）记录体感诱发电位（SEP），这是一种更敏感的损伤标志物。在麻醉诱导前、麻醉诱导后、VF诱导前及诱导后的几个时间点记录SEP。在整个手术过程中，SEP测量的可能影响因素，如麻醉应用、血压、体温和血细胞比容保持恒定。中央传导时间不受ICD除颤测试的影响。除颤测试使SEP主要复合波的幅度短暂降低了34.9%（P < 0.01），但在测试后10分钟内恢复至对照水平。结论是，虽然ICD除颤测试可能会使SEP产生短暂变化，但没有证据表明存在残留脑损伤。
